Rybrevant: Cost, how it works, side effects, dosages, and more - Medical News Today

Rybrevant can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while receiving Rybrevant. These lists do not include all possible side effects.

For more information about the possible side effects of Rybrevant, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Keep in mind that the Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you've had with Rybrevant, you can do so through MedWatch.

Mild side effects

Mild side effects of Rybrevant can include:

* For more information about this side effect, see "Side effect details" below.

Most of these side effects may go away within a few days or a couple of weeks. However, if they become more severe or don't go away, talk with your doctor or pharmacist.

Note: This is a partial list of mild side effects from Rybrevant. To learn about other mild side effects, talk with your doctor or pharmacist. You can also see the drug's prescribing information, which may be referred to as the Rybrevant PI.

Serious side effects

Serious side effects from Rybrevant aren't common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.

Serious side effects and their symptoms can include:

• Eye problems, such as keratitis (inflammation of the cornea) and uveitis (inflammation of the middle layer of the eye). Symptoms can include:
  • changes in vision, such as blurry or cloudy vision
• Infusion-related reaction.*
• Lung problems.*
• Severe skin reaction.*
• Allergic reaction.*

* For more information about this side effect, see "Side effect details" below.

Side effect details

Here's some detail on certain side effects this drug may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Rybrevant.

Infusion-related reaction

Rybrevant is given by IV infusion.* So, some people may have an infusion-related reaction with this drug. This is a side effect that happens during or shortly after your infusion.

In clinical trials, infusion-related reactions were common with the first dose of Rybrevant. They were much less common with the second dose and rare with later doses.

Most infusion-related reactions are mild, but on rare occasions, they can be severe. Symptoms of an infusion-related reaction may include:

What you can do

To help prevent infusion-related reactions, your doctor or another healthcare professional will give you certain medications before your Rybrevant infusions. Before your first two infusions, they'll likely give you:

You may not have a severe reaction to your first two infusions. In this case, your doctor will likely give you only an antihistamine and acetaminophen before your later infusions.

If you have symptoms of an infusion-related reaction, tell your doctor right away. They may give you medication to help ease your symptoms.

Depending on the severity of your symptoms, your doctor may also slow down or pause your infusion. However, if you have a very severe reaction, they'll likely recommend you stop Rybrevant treatment permanently.

* For more information about how Rybrevant is administered, see the "How Rybrevant is given" section below.

Lung problems

Rybrevant can sometimes cause lung problems. These include:

In clinical trials, lung problems were rare with Rybrevant treatment.

Symptoms of lung problems can be similar to symptoms of lung cancer, which Rybrevant is prescribed to treat.* They may include new or worsening cough, fever, breathlessness, or trouble breathing.

What you can do

If you have new or worsening lung symptoms, such as those described above, see your doctor right away. They'll likely stop your Rybrevant infusions while they treat the problem and figure out the cause of your symptoms.

If your doctor determines you have interstitial lung disease or pneumonitis, they'll stop your Rybrevant treatment permanently.

* For more information about the approved use of Rybrevant, see the "Rybrevant uses" section below.

Skin reaction

Some people may have a skin reaction, such as a skin rash, during Rybrevant treatment. In fact, skin rash was the most common side effect reported with this medication in clinical trials.

Most skin reactions with Rybrevant are mild. However, severe reactions, such as toxic epidermal necrolysis (TEN), are also possible. (TEN is a serious, life threatening skin reaction caused by certain medications.) In clinical trials, severe skin reactions were rare with Rybrevant treatment.

Symptoms of a mild skin reaction may include:

Symptoms of a severe skin reaction may include:

What you can do

To help prevent skin reactions with Rybrevant treatment, you should try to limit your sun exposure during treatment. You should also do this for 2 months after your last infusion.

If you go out in the sun, be sure to cover your skin with clothing and wear a hat. You should also use sunscreen. If you have dry skin during your treatment, you can also try using an alcohol-free moisturizer.

If you develop a skin rash or other skin reaction during treatment, see your doctor. They may reduce your Rybrevant dose or pause your treatment until your skin reaction gets better. To help ease your skin reaction, your doctor may prescribe medications such as topical corticosteroids (steroid creams or ointments). They may also prescribe antibiotics that you'll apply to your skin or take orally.

If your skin reaction is severe or doesn't get better within 2 weeks, your doctor will likely refer you to a dermatologist (a doctor that specializes in skin). They may also recommend stopping your Rybrevant treatment permanently.

ALLERGIC REACTION

As with most drugs, some people can have an allergic reaction after receiving Rybrevant.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• trouble breathing

Call your doctor right away if you have an allergic reaction to Rybrevant, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.